Bit early for restrospectives and there may be more on the way deserving of this list, but here they are so far. Maybe I should visit my local GameStop, where I can buy and sell used games!
 
Saint's Row 2 - I just could not get into this game.  
Star Ocean: The Last Hope - Just really mediocre in every way except for combat. Couldn't get more than a few hours in. 
Far Cry 2 - It felt like just another FPS to me, did not enjoy it as much as I expected to. 
Sacred 2 - Jury is still out on this but I'm already regretting it, at least playing it on a console. 
Guild Wars - Thought this might scratch the ol' MMO itch. It did not.
Maboshi's Arcade - This seems to get a lot of praise but I still haven't gotten around to playing it, so I probably could have done without it. 
 
Everything else I picked up this year? We cool.