I'm betting that Dishonored 2 and Doom 4 will be part of the conference as well as a new game by the Wolfenstein guys. Crossing my fingers for a resurrected Prey 2.
I'll only care about a Fallout 4 if they have Chris Avellone writing it. The difference in quality between Fallout 3 and New Vegas when it come to dialogue, quests and choices is insane.
Honestly I hope they give Prey 2 to the Wolfenstein guys