I was re-playing Mass Effect 3, using my other Shepard character - the renegade female one when I suddenly found something very interesting. While I was still choosing renegade options, I found myself actually agreeing with them. Let me explain. On my first playthrough of the series, I was Paragon Male Shepard. In Mass Effect 2, I had managed to defeat the Collectors with only one casualty... my love interest, Tali. Everyone else lived and in ME3 I found myself rekindled with my old flame Liara.
I cured the genophage for my old buddy Wrex and his new hunny, I mourned as Mordin sacrificed himself to get it done. I sided with Legion when it came time to choose between the Quarians and the Geth... without Tali's influence, the Quarians all perished... I felt I had done everything I could to get them to see reason, and their destruction was their own doing.
I rescued the Rachni Queen... again... and managed to keep Grunt around in the process. Garrus came back to serve under me, I saved Jack from Cerberus, Miranda died in my arms saving her sister, I shook Jacob's hand as he announced he was going to be a father, I kept Samara from killing herself over the death of her daughters, I even convinced old Zaeed to stop his merc ways and join up against the Reapers... and I literally got a bit misty at the death of Thane.
All of that was very satisfying, if not a bit "what a coincidence! You!" about it all. Then that ending... just tore me up that it seemed all ruined by that.
Then, I played my renegade... the one where out of all of those characters from ME2, only Garrus and Grunt survived. No one else.
Garrus joined me again and that was great... but I got to Jack's school and she wasn't there. Her students were on their own, and not all of them survived the attack. Miranda was replaced by her sister discovering the bad news about her dad. Jacob's child would never be. I ended up putting a bullet in the last of Samara's children. Thane wasn't around to stop the assassin and we lost the Salarian councilor. Tali was still not around, but this time... neither was Legion. Just an AI duplicate of him that I didn't trust. The Geth were wiped out. A clone of the Rachni Queen? I don't think so. Left her to die. All of that was different, and interesting, but nothing as interesting as the genophage differences.
Urdnot Wreav was the main Krogan this time... see, I killed old Wrex way back in the day. Mordin was long dead, so his replacement, the not-nearly-as-talented, but still brilliant salarian scientist Padok Wiks was there to help in his place. This character, truly, was a delight. He was eccentric, like Mordin, but in different ways. He actually had faith in some sort of spiritual Creator which was very un-Salarian of him. He was also funny and piont-blank asks Eve how Krogan mate. Her answer? Very clumsily. And Wreav... all he talked about was revenge for the genophage. Something Wrex would be against if he were still here. So when offered the deal by the Salarian Dalatrass? To fool the Krogan into thinking they are cured when they weren't? I took the deal. And when Wiks confronted me about it... he decided he agreed. See, Eve had died because Wiks was unable to stabilize her immune system, unlike Mordin. Without her guidence, Wreav would become a despot. Wiks and I both walked away as the faulty cure was spread. The Krogan would continue to be practically unbreedable, and peace would prevail. Had Wrex survived or Mordin... that might have ended a lot differently. But since they were both gone, I did it gladly. Something I never would have done against Wrex when given the same choices.
Anyway, I found that very interesting. I have heard that there is a way to spare the Quarians AND the Geth and I have a 3rd playthrough of ME2 with all members surviving to try it out with. All in all, my disappointment about the ending is still there, but my admiration for the game and its story from beginning to *almost* the end has been uplifted and is quite profound.