You can do it before or after, I have done both, but I suggest doing it after the game when you don't have much else to think about other than doing that mission. The only thing that really changes is the conversation you have with Liara if you ask her to aboard the ship.
First time I beat it when the game came out, I didn't pay enough attention I guess, to know that I had to upgrade the ship, and the whole paragon renegade was beyond me even though I had played the original back in 07 (I didn't originally care for the original so I didn't care much about how the game had worked). So Jack, Legion, and Zaeed died. I had them all loyal enough to survive, but because the lack of ship upgrades and sending Zaeed to do the wrong job on the suicide mission, those three died. Then after that (I don't remember how long after, but it was a good chunk of time), I had bought it off steam and beat it again, less worried about it, so I went through it, and as I went through it, I started understanding it more (I think this is how it went?), and after beating the PC version I understood the paragon renegade mechanic, knew about who to take on the suicide mission, but did it wrong, 'cause I somehow killed off Mordin.
After beating the PC version, I went back to the original Mass Effect on 360, understanding exactly how the games work, so I went through Mass Effect once again, doing all the paragon, but in that play through, I had chose to kill the council which in fact was a renegade choice indicated at the beginning of ME2, so after playing almost half way through two again, I said "Fuck, this sucks, but I'm going to go through ME1 and like I want to do with ME2, I'm going to do every little thing I can, and also save the council." So I went back to ME1, did every single side mission, visited every planet, did paragon everything, I noticed that spending all that time with ME1 again; I appreciated it a lot more.
The one problem I had with that play through, that I never had happen in the previous two times I played it before, was not helping Gianna Parasini (though I did get the paragon) on Noveria. So in the second game, she never kissed me at the end of the conversation once you meet her on Illlium. Boo whoo right? Anyways, yeah, that happened. Got through ME2 again, accidentally got Kelly killed by not going to the end mission fast enough since I did everything I could in the game before going to the ending, yeah, hours after. Didn't like that, so I went through it again about a month and a half ago, did everything paragon like I wanted to, saved Kelly, though if you save Kelly, it kills off the Lilly, the colonist taken from Horizon. So now, I am happy. I am ready for three. Every single thing in the Mass Effect universe so far, is done. Only one thing I couldn't do from the first game since I'm a soldier and you had to be something else. I don't care about that though.
Now the only small problem is that I didn't play Overlord and Arrival.
Uhhh. Awesome. If you can, which I'd be thankful if you could, please draw a picture of Solid Snake, Sam Fisher, Batman, Agent 47, and James Bond together. If you would take the time to do so, that would be cool. If you do my request, make sure it seems like they are in the same world, and that they know their surroundings. I'd rather not have it so it just looks like their copy and pasted next to one another. If you do decide to make this lofty picture, be sure to get it to me with a reply and not just by posting it on here, 'cause if this thread is buried later on, I won't think to come back and see it unfortunately. THIS WOULD BE AWESOMMMMEEE!
Looks like they were testing the game out (from all of the things on the side of the screen), and they used the assault rifle, other than that, it's not very good footage at all. Whatever though, I guess you should be thanked for showing us, so... thank you.
OK, so yesterday, I had finally bought this game, and I played it for a good amount of hours until early this morning before I decided to go to sleep. Anyways, I think I have about four or five hours left, I'm not entirely sure, but what I want to know is before I start playing again, will I be able to do all the side missions after I beat the game? At the beginning, the one little thing I disliked (though still like in a way) was that I felt overwhelmed with side activities, 'cause I want to do them all, but there came a time very early on that I had decided to just do them all after the game instead of trying to cram them in with the rest of the main story, will I be able to? Can I even play on, on the same profile after the game's finished like Arkham Asylum (no spoilers required)? Thanks.
@golguin: There isn't going to be a huge impact. I've only played the Shadow Broker mission, and wished I played the others (Overlord and Arrival), but I didn't. They say they're not going to punish the person who doesn't play it, so hopefully that answers your question.