A significant number of Skyrim mods are dependant on other mods. I have to wonder how that will function in this new economy. Also, how retextures and remodels will work. Will one modder need to pay another modder from their profits? If both mods are necessary to function that might not be an issue, but there are plenty of stand-alone mods that take elements of an earlier mod and kick it up a notch. A lot just update or convert a mod to work with a variety of base mods. It's going to be intersting to see how this plays out.
I must say, though, I am a little less excited for Fallout 4 than I was a week ago. I fear that the creative community I've followed for years will grow splintered and suspicious of each other. After all, money changes everything. On the otherhand, change is inevitable and nothing good lasts forever.