Had a run yesterday where I successfully completed The Dark Room and defeated The Lamb without taking damage at all and got the Dead Boy achievement. That felt like quite an accomplishment. I'm not sure I'll ever hit Platinum God and I'll probably wind down my playing a bit now because there are a few other games I'd like to get to, but I feel pretty good currently sitting at 110/178 achievements in 55 hours of play. This game has been some amazing fun.
The only thing I haven't had the chance to do yet (mostly because it's hugely luck based) is getting to and defeating Mega Satan. I got to him once and only lasted about a minute. :/