(the fuck is up with these forums? My original post didn't even get posted...)
I think she's a talented, well-rounded actress which you would very much need for a character like Motoko who can often be quite complex so I'm not too worried about casting. It's the fucking director that scares me. Nothing he has done fills me with the least bit of confidence. That said, I'm hoping...praying to the gods I don't believe in that you don't try to tackle something like GITS without some sort of reverence for the source material and a decent budget to match. But then again, this is Hollywood so...man, I dunno.
For all of his (numerous and far reaching) faults, Rupert Sanders is a massive anime fan. I don't need to know anything about him to know that. Simply watch Snow White and the Huntsman. The movie is basically a combination of Nausicaa and Princess Mononoke. The sequence with the forest God/spirit is lifted almost shot for shot from the nearly identical sequence in Princess Mononoke. And the spirit itself looks almost identical to the one in that film as well. Plus the story is about a princess who uses her ability to charm animals to free her peaceful kingdom from the clutches of a warlike nation bent on the destruction of nature. It includes a warrior queen and her bumbling male general as the main villains. I was surprised there was no Joe Hishashi soundtrack going on in the background it so deeply stole from those two films. So reverence to the source material should not be a problem.
As for Scarlett, she's got the action rep from Lucy and the Marvel movies, and the philosophical/meaning of life rep from Her and Under Her Skin. She's basically played all parts of this role in other films. I honestly couldn't have named a better actress. As far as her not being Japanese, well the whole point of a Hollywood remake is to take a foreign film and reframe it as an American one. That is what I always expected it would be. If they want to keep an oriental setting they could set it in China. Big audience there with an affinity for films about robots (I know she's an android) and the nation has the know how and finances to believably be able to create a society like the one in GITS.
The thing I'm most curious about is are we going to get a more humorous take like the show/manga or an ultra serious, hyper-violent take like in the movies? Personally I'd prefer dark and violent, but that would probably be a harder sell. That said GITS did directly inspire The Matrix which was a violent, sexual, R-rated philosophy course so it could happen.