@cerebus: Check out the Tram if you're not afraid of heights. Eat at Sadie's, any of the locations are fine but I still prefer the one up on 4th street, the food is very hot so order chile on the side if you need to. Find a Golden Pride and have a breakfast burrito(most places make good ones, this is just my go-to, pretty good Carne Adovoda). Old town is nice this time of year to walk around and checkout some local artists and vendors. Weems International Artfest is at the fairgrounds this weekend if you're into that, it's usually a pretty cool event with lots of interesting artists. The National Museum of Nuclear Science and History is pretty cool to kill a few hours. If you're the outdoors type there are a LOT of places to go hiking or biking. We have a VERY nice aquarium and if you go there take a walk through the botanic gardens as well.
Edit: OH, Bring a jacket, its cold this weekend, Highs will be in the 40's on sunday. Shut up, that's cold here.