If it's your first time, I imagine so. If it was your fifth time, probably not. I'm still on my first playthrough (picked it up for $7 around the Steam sale) and I modded the shit out of it, so I can't speak from experience, but it seems like the vanilla experience would be totally fine. It'd probably get tiring on later playthroughs, though.
Modding isn't that difficult, though, if you use the mod site Nexus and install their Nexus Mod Manager software. It does the installation work for you for most mods, and when mods require manual installation, it's usually easy enough if you follow the modder's instructions. Try out a simple mod or two. You'll probably be fine.