I was honestly disappointed that Vinny didn't take over regular hosting duties. He's simply so much more sociable and lighthearted, whereas Jeff is at his best when he's not pretending to be either sociable or lighthearted. Vinny also seems to enjoy a good conversation the way Ryan did, whereas Jeff is almost always focused on making a point or asserting an (often strong) opinion.
I recall Phil Fish saying "I'll probably kill myself" if FEZ isn't successful, dead serious, to the Indie Game: The Movie camera. I don't suspect Fish is capable of much else outside of game development, so for his sake, he'll come back.