Just picked it up one day in the bargain bin of EB Games (this was back in like, 2005) and played the ever-loving shit out of it. To this day there's nothing quite like it. It's got atmosphere out the ass, great characters, a rather unique leveling/experience system, and unlike most "play how you want" RPGs I can actually get through 98% of this game without initiating combat at all.
It's probably the first RPG about role playing I ever played. Up until I played VTMB I thought RPGs were just about numbers and leveling stats. This shit right here spoiled me and it really grates on me that there hasn't been anything else like it since.
I second this, and also submit :
I bought Z.O.E. solely beause of that MGS2 demo. Once I played the boat like a thousand times I decided to pop in the game and was delighted to find a very fun and heartwarming game about a boy and his robot. I loved it from then on. ZOE2 was great as well, but Leon Stenbuck will always be my Runner.