Most of my nominations are 5 games each. I did make an exception for a few because man...there was a lot of good games this year 

Best Re-Make (To define re-make, I mean games like Wolfenstein, etc. But straight up re-makes such as Punch Out!! still count)

Boy and His Blob
Punch-Out!!
New Super Mario Bros.
Monkey Island Special Edition
Trials HD

Best Sequel

Ratchet & Clank Future: A Crack in Time
Skate 2
50 Cent Blood on the Sand
Red Faction: Guerrilla
Call of Juarez BiB
Assassins Creed II
Modern Warfare 2
Killzone II

Best New Franchise

Dragon Age: Origins
'Splosion Man
Shadow Complex
Brutal Legend
Borderlands

Best War Game

Halo 3: ODST
Operation Flashpoint Dragon Rising  
 Battlefield 1943
Modern Warfare 2
Killzone II

Best Shooter

Ratchet & Clank Future: A Crack in Time
50 Cent Blood on the Sand
Call of Juarez: BiB
Modern Warfare 2
Borderlands

Best Extreme Sports/Traditional Sports Game

Skate 2
Madden NFL 10
NHL 10
Fifa 10
The Bigs 2

Most Disappointing

 Prototype
Bionic Commando
Ninja Blade
Uncharted 2: Among Thieves
Academy of Champions: Soccer

Best Music/Rhythm game

 The Beatles: Rock Band
Guitar Hero 5 

Most Surprising

50 Cent Blood on the Sand
Red Faction: Guerrilla
'Splosion Man
Brutal Legend
Torchlight

Best Fighting Game

WWE Smackdown vs. Raw 2010
Legends of Wrestlemania
Street Fighter IV
King of Fighters XII

Best Graphics/Art Style

Pixel Junk Shooter
Uncharted 2: Among Thives
Modern Warfare 2
Red Faction: Guerrilla
A Boy and His Blob

Best 360 Game

Shadow Complex
 'Splosion Man
Left 4 Dead 2
Rocket Riot
Grand Theft Auto: Episodes From Liberty City

Best PS3 Game

Pixel Junk Shooter
inFamous
Fat Princess
Killzone 2
Ratchet and Clank FutureL A Crack in Time

Biggest Announcement

Something probably happened.

Best Soundtrack

Assassins Creed II
The Beatles: Rock Band
Brutal Legend
'Splosion Man
Uncharted 2: Among Thieves

Best Storyline

Batman: Arkham Asylum
Assassins Creed II
Brutal Legend
Call of Juarez: BiB
Dragon Age: Origins

Best New Video Game Character

Ezio
'Splosion Man
Eddie Riggs
Cole
Afro Samurai

Best Co-op Game

Borderlands
 New Super Mario Bros.
Pixel Junk Shooter
Unncharted 2: Among Thieves
South Park: Tower Defense Go

Worst Game This Year

Eat Lead: The Return of Matt Hazzard
Prototype
Damnation
Wheelman
Backyard Football '10

Game of the Year

Batman: Arkham Asylum
Modern Warfare 2
Assassins Creed II
The Beatles: Rock Band
Torchlight
Brutal Legend
Call of Juarez: BiB
Red Faction: Guerrilla
50 Cent Blood on the Sand
New Super Mario Bros.
Ratchet & Clank Future: A Crack in Time
Borderlands
Left 4 Dead 2 
 
Winners will be announced on Christmas Day.