Fallout New Vegas is the best RPG of the last generation. The story might be more linear than Fallout 3 but most factions and communities are interesting and different compared to the stereotypical tropes of Fallout 3 that seem like conscious fan service. Deathclaws are an actual threat as well.
There was a game breaking bug on Xbox 360 that was patched (something about a Sheriff's hat in your inventory in New Vegas). I guess I've played over 200 hours on PC with mods and the only major issue I had was a consistent crash at a spot inside the airport. It was nothing game breaking because it wasn't an important environment. I can't remember if I found a workaround.
You might not be able to run around the most densely populated areas with the highest settings because that was weirdly demanding.
If you save your game frequently you should be alright.