Nothing on my end. Played the 360 version and also didn't mess with any of the sensitivity options. Found everything to be on target. To be fair though, Starbreeze always had a weird, yet oddly satisfying way of handling shooters.
The only people who died on my first playthrough was the Normandy crew since I didn't go immediately after them after they were taken by the collectors. Other than that, all the important people were alive.