I find that with these kinds of games, I'll play them exclusively until I feel like I had my fill. I'll stop and play something else and forget about it for a bit then pick it back up and play it like crazy until the end. It's all about pacing my man.
I'm just put off by the fact that all I really here from people is "You HAVE to play Saints Row: The Third". Pretty sick of it now. Yes, we get that the game is shit on the wall cuh-razy, but if I want to play it, then I'll play it.