I'm still playing the hell out of fallout 3 and during my travels I stumbled upon a neat quest.
 
The Nuka Cola Challenge
 
I loved the tour of this eccentric girls Nuka Cola collectibles, it gave  the character  an "edge" that so many other quests/characters lacked. 
If they (the developers) had put a scripted event or some believable characters elsewhere such as Paradise Falls; it would have worked wonders on some of the stale 
pieces of Fallout 3.