Okay, so let me just say that I beat the last level again, and I'm really going to be pissed off if Wesker comes back in the sixth game ( Because this is Capcom, there will be a sixth game ).. Seriously, you do not survive being surrounded by lava AND a fucking RPG to the goddamn face. Capcom better shut the fuck up and just let Wesker from the Matrix die srsly.

It would be incredibly strange to see him come back after that.

Of course, I kind of want him to come back next time, cause he was actually a decent villain. And maybe have Jill actually, you know, do something against him. They should pull a super-Terminator sort of thing, and just when you thing he's dead, bring him back. And then do it again, and then again, and then one more time for good measure. I'd laugh.

since when does death mean anything in Resident Evil? 

They should work on a new villain at least. Or perhaps work on making more memorable side villains. Irving and Big TIts? Who the fuck are they and why should anyone care? Irving is around for like 5 minutes total, but he has a great character design.

Irving is actually the antagonist in 2011's RE6: The Search for the RE4 Merchant: Origins. 

Ohhh that explains it.

He'll probably be back.  Given Wesker's origin story as revealed by Spencer, he'll be worked back into the plot in some shape or form.

It honestly wouldn't bother me.  For someone who practically orchestrated the entire series, he wasn't given a proper send off at all.

It would suck if wesker died.

"

It would suck if wesker died.

"

Maybe hell come back...as a zombie.

*Dramatic music plays (send me some good ones :D)*

"He'll probably be back.  Given Wesker's origin story as revealed by Spencer, he'll be worked back into the plot in some shape or form.It honestly wouldn't bother me.  For someone who practically orchestrated the entire series, he wasn't given a proper send off at all."

He contained uroburos so... als the rocket could have blasted him out of the lava. Don't forget, in the earlier fight, it's not like a rocket even kills him.