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Adrian is the main antagonist of Little Nicky and the final boss of the game.
An Einherjar in Valkyrie Profile: Lenneth. Aelia is an adventurer who has the power to transform into a dragon.
The "shape shifting demon" from the Samurai Jack cartoons on Cartoon Network. He was almost defeated by Samurai Jack, but he cast a spell that sent Jack into the future, where he was much more powerful and had a lot more allies.
The protagonist of Prototype, Alex Mercer has been transformed by a virus into a shapeshifting weapon. He seeks to uncover the mysterious source of his abilities as well as fight the same virus as it consumes Manhattan.
Dracula's not-quite-so-loving son from the Castlevania franchise. He is a vampire who fights against his father on the side of good.
I like his sphinx counter-attack
Bayonetta is the titular character of the 2010 PS3/360 action game from Platinum Games. The angel-hunting witch comes complete with guns on her feet and hair that morphs into stilettos and dragons.
Known as both the First Damned and the Dark Master, Be'lakor was the very first mortal to ascend to Daemonhood, but was passed up by the four Chaos Gods as a candidate for the Everchosen. Nevertheless, he is a proud follower of Chaos.
A green boy who changes into different animals. He is a member of the Teen Titans
Bigby Wolf also known as The Big Bad Wolf is the main protagonist of Telltale's The Wolf Among Us, based on the comic book Fables.
Gon and Killua's kung fu and Nen trainer.
The son of Mephisto, the Devil, Blackheart is a powerful demon who wishes to overthrow his father as Lord of Hell.
Blobert is the blob character from David Crane's A Boy and His Blob. By being fed jelly beans he could transform into various useful items.
The source of more nature metaphors than man ever knew existed.
The main character of Mugen Souls.
A daedric prince whose sphere is the granting of wishes. He's accompanied by Barbas, who seems to be the manifestation of Vile's conscience and is the only thing keep this Daedric Prince under a semblance of control.
Clayface is a villain in the Batman universe. He's made entirely out of clay and can change his appearance at will. Throughout Batman's life a number of different people have taken on the alias of Clayface.
Cronos is a character in the Bloody Roar series, who has the ability to transform into a penguin and an even more powerful Phoenix.
A concubine of a Chinese king said to be responsible for the fall of China's Shang dynasty.
An incredibly powerful Vampire, Dettlaff was an instrument of Syanna's vengeance, who took advantage of his feelings for her to eliminate her enemies. He is the final boss in the Witcher 3 expansion Blood and Wine.
Diego Brando is an antagonist and a neutral character in the JoJo's Bizarre Adventure chapter7, Steel Ball Run.
A character in the Guilty Gear series. She is a Gear who fights very similarly to Justice and was the boss in Guilty Gear X.
A shapeshifting Genie who is among the many bosses in Cuphead
Dog is a mysterious magical spirit that contacts mortals through it's network of shadowy canine messengers. Dog will often ask for favours as an initiation test before communing directly with mortal beings. Dog is able to grant magical powers to its followers. Jake Armitage is granted such powers by Dog who has a secret shrine in Seattle's docks.
An ally of the Skullgirl. This nightmarish creature can assume the form of any person, most frequently a smiling nun.
The DracoLord is the arch enemy of the first Dragon Quest game. His grandson also appears in Dragon Quest II, and aids the party. In earlier versions of the game, he was called the Dragonlord.
One of two classes added in the "Lord of Destruction" expansion pack to Diablo II, the Druid can channel the powers of nature against his enemies, summon spirits and creatures to aid him, or transform his body into a nimble werewolf or hulking werebear.
Eir Stegalkin is a norn hero who roams the icy Shiverpeaks with her wolf companion, Garm.
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