@MasterRain: I guess don't see a problem with that scene in the game. Perhaps their problem is that it's supposed to be a humorous scene, and the trans person is made to be a joke. But, honestly, that's a natural reaction to discovering that a woman you are initially attracted to has undergone a sex change operation. I've never really experienced this first hand, but I know I wouldn't just shrug my shoulders and move on. Perhaps I'm a terrible person, but I wouldn't date a transwoman. I would absolutely never want to marginalize transsexuals, or think of them as lesser people, or do anything like that, but I would never date one.
You cannot display the negative aspect of society in media unless you explicitly show its negativity in a fable sort of way. You must show how society SHOULD act. A lot of people are casually racist and sexist in real life, but you cannot show that in media as it projects that it is acceptable.
I am usually one to hate all this political correctness bullshit, but you cannot reinforce negative stereotypes. These videogames are the rolemodels of youth, so when they grow up they don't think transgender people are weird.