Notables uses of smoking in video games
Metal Gear Solid
In the first three MGS', smoking provided the benefit of allowing the player to see nearby infrared laser traps via the cigarettes/cigars smoke, which is especially useful should players not have located the thermal goggles. However smoking does still in fact harm the player character, as it'll very slowly cause it to deplete their health bar the longer they have cigarettes equipped. Though it will only deal damage to a certain point and cannot actually kill the player character.
In Metal Gear Solid 4, Snake can smoke cigarettes to regain his ''Psyche'' meter, which determines how well Snake can perform in-battle, such as handling recoil and being able to aim steady.
In Metal Gear Solid V: Phantom Pain, Big Boss has available a ''Phantom-Cigar'' that is filled with a drug that speedens the character's perception of time, introducing the opportunity to fast-forward the clock.
Much like Phantom Pain, Francis York Morgan can smoke a cigarette to speed up time. However there's no actual in-game explanation as to how this occurs.
Should it have been unlocked, and so long as the player has a cigarette available in their inventory, one of Kazuma Kiryu's HEAT moves is initiated by him flicking a cigarette towards an enemy's eyes stunning them as a counter attack.
Grand Theft Auto V & Saints Row/Saints Row 2
In most open-world crime games of the Grand Theft Auto & Saints Row nature, players can often partake in smoking marijuana. This will typically then make the screen slightly sway, imbue a number of faded colors on the screen, and/or slow-down the action slightly.
In GTAV Franklin has available a lit joint at his safehouse to smoke; in Saints Row 1 + 2, players can buy marijuana joints to store in their inventory for use.
While it provides no mechanical benefit, one of protagonist Sean Devlin's idle animations is of him smoking a cigarette, to which he'll flick away as soon as the player retakes control. Sean's smoking occurs in real time at that, and he can eventually smoke through an entire cigarette. In the game's statistics menu, there is a stat that tracks how many cigarettes Sean has smoked.
Chris Redfield of Resident Evil fame was initially depicted as a smoker during the original Resident Evil's opening FMV cutscene. However it wasn't until Resident Evil 6 that his habit was reintroduced; up until that point there was otherwise no indication as to whether he continued to smoke.
While Chris isn't shown to smoke this time, his unique inventory item in the Resident Evil remake is of a lighter. As it is for Leon S. Kennedy during Resident Evil 2, however he has never been shown to smoke. During when Leon first encounters Luis Sera in Resident Evil 4, Luis asks if Leon has a ''smoke'', to which Leon responds ''got gum''. Though whether Leon has gum because he has been trying to give up smoking--if he was even a smoker to begin with--is unknown.