I just finished The Amazing Spider-Man, the story was kind of so so throughout, nothing big happened and I really hated how instead of great villains like The Scorpion or the Rhino we get fake versions of them. They don't speak or exchange banter they just fight, which was a huge bummer as everything felt like a cop out. As I was playing through the game it all felt rather familiar, you know a small virus starts and as the game goes on it gets bigger and bigger and bigger. Well then I remembered that Spider-Man: Web of Shadows totally did this already, Web of Shadows was the last good Spider-Man game before they were sold to Beenox.
Web of Shadows Story was Venom slowly started infecting people, it started soon but not to far in the future it increases and increases until most people are then infected. It will also infect other superheroes and villains making you fight them, see how this is familiar?