Just getting out of the prologue and I have already amassed an inventory hoard of cloths and leathers and dust. I am coming off of the Witcher 1 where there was a lot of stuff to pick up but nothing along the lines of this game.

I need to stop myself early if I am to survive, should I be picking up every single item, opening every door I can, and searching every single drawer and sack I find, or can I make it through the game on easy not bothering with this?

Pick up things that seems rare like silver and prestine materials and such like that.

Basic things like cloth and the likes of that you can gather together quickly when you need it.

Rare monster parts are also worth saving. There are some monsterparts which you only get early on that you need for end game stuff which is a bit irritating. I usually sell everything i dont need and if its something i find out i needed 10hours later cheat engine is my friend.