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Yoko is a shy and reclusive student, or at least appearing as such to the other characters. In truth, she was an UMBRELLA scientist, who committed an apparent atrocity, to which she has no recollection of.
Yoko is a very frail individual, and has the least health, running speed, and she has the slowest firing animations with weapons. What she makes up, though, is her handy ability to carry twice as many items as any other character - essentially having her take the role of the teams pack mule.