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Amy Chase is the eight-year-old sister of Dr. Tyler Chase in Trauma Center: Under the Knife and its remake, Trauma Center: Second Opinion. Hospitalized with a serious illness, it had spread too far before its detection, leaving little hope for her survival. Her brother Tyler plans to euthanize her so that she no longer has to live in suffering. However, Dr. Derek Stiles convinces Tyler to let him operate on her. He manages to save Amy's life by performing surgery and extracting the GUILT infection before the disease can kill her.

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