1. Revolutionary France.
2. Colonial America
3. Russia, during some early interesting time period.

Just saying, this should be a legit poll. Of the three, I think France would be the best story wise, but Russia would be the best in terms of badass looking buildings. But they have a comic about assassins in Russia, so I don't know if they'd want to carry that over into a game. 

Tha moooon

Colonial America would kinda suck because of the lack of architecture. Perhaps sometime before World War 1? Some industrial era. Although, maybe that would suck too. It's tough to say where it should be considering it is an architecture heavy series. So what period of time after Brotherhood would be right to climb and run around in?

1911 Chicago

Gotham City. You find out one of Desmond's ancestors is Batman.

nah nah nana naaaaahhh

Victorian London, maybe?
 
Edit: But that would probably be better for Asscreed 4, so I'd say Revolutionary France.

" Gotham City. You find out one of Desmond's ancestors is Batman. "

Victorian London

Okay, in the assassin's we have a bunch of very agile shadow warriors who pit themselves against traditional authority. Where, in history do we have a similar type of warrior? Why, the ninjas in Japan of course. Japan even comes equipped with its own unique architecture and in AC: Brotherhood  *spoiler* it was revealed that there was an assassin team based in Japan *end spoiler*. The only problem is fitting the Altair bloodline in. Altair and his descendants seemed to live around the middle east, Europe, and eventually the U.S.A. and Japan was largely an isolated nation for much of their history. Maybe we could have a spin-off with a different main character and a different set of ancestors. I would also love to see a western gaming company's take on Japan.

Colonial America? Were supposed to have fun watching Ezio climb a two story farmhouse?  
 
Russia during the revolution could be kinda awesome. 

in a vacuum is the first thought that come to mind... 
 
 
a Bissel upright.

The rumoured  Feudal Era of Japan sounds really appealing, it could be a completely different take on an Assassin story. 
 
I don't know viable it would be, but I remember it being mentioned in one of the developer interviews at one point.

The modern day, New York City, or something like that. I would love to finally play as Desmond throughout the game and work with the other assassin teams. 

" Colonial America? Were supposed to have fun watching Ezio climb a two story farmhouse?   Russia during the revolution could be kinda awesome.  "

As far as time period, it better be 2012. If it isn't i'll shoot my brains out/

Well first of all since there's is going to be another game coming out this year in the same vein as AC: Brotherhood, I'm pretty goddamn sure that this Brotherhood 2 (let's just call it that) is going to keep going again with Ezio although I could be wrong. Mainly cause in the ending of Brotherhood  
 

Kuala Lumpur, Malaysia.
 
Because we know games all have to take place in Russia, Vietnam, the US, or Europe. So let's change things up a bit.

Revolutionary France is one that I've been thinking about for a while. 
 
I assume that all the time periods will keep going up until we finally get to the present.

There was some rumor it was egypt, I don't care where it takes place at.

" @SuperBuster: there is no reason that it has to be Altair's bloodline. Desmond could have assassin ancestors from all over the place. "

they a;ready did a comic for revolutionary Russia, it might be a cool game though. I vote for that, hanging with my homie Lenin would be cool!

Revolutionary France or Colonial America would be awesome.

" Colonial America? Were supposed to have fun watching Ezio climb a two story farmhouse?   "

" @Ihmishylje: duh, but i togt dat bloodlin was  line mad fo bllod. "

Space.

well a modern AC3, meaning 2012, in a modern city would make me nervous, ad it seems like it would be hard to implement central mechanics, such as crowd blending and climbing, in the modern day world

Russia would mos def be cool.  But c'mon, they HAVE to set the next game in the modern day.  This totally gets me excited because if there's a big open modern world, I wanna see how they get around the rooftop traversal.  Desmond obviously can't  jump from a skyscraper to a smaller building or he'd kill himself.

Modern Day and wherever Desmond is now.  We need to stop stabbing dudes in the past and kills some contemporary Templars.

Victorian England or some place in Europe during the late 1700s/early 1800s. 

In my pants!!!

I'm standing by half the game taking place in World War II as Desmond's grandfather, ending with you interrogating Hitler and finding out where that Piece of Eden is being hidden. The other half of the game should be actually played as Desmond, as this is really where the series needs to go; his grandfather is mostly here to train Desmond with firearms, to fulfill the "era" quota, to give us an awesome time period to play in, and to bridge the story between the end of Brotherhood and where III needs to go.

2012 is all i want to see now for assassin's creed 3 
 
but i would fucking love to see more offshoot assassin's creed games, like they were saying on the podcast when they were talking about the other teams and stuff it could really open it up for side stories

Inside of my house.

" Space. "

Feudal japan.

I'm also a fan of the Moon. That series is so crazy, they could work it in somehow.  
 
@SuperBuster said:

" @adoggz: they are descendants of a union between a human and one of those-who-came-before   

My money is on it being during present day Desmond, or ancestors in France or England. 

Ooh, Victorian London might be fun. Maybe the gritty streets of New York in the 70's, where you have to fight The Warriors.
 
Also, you shouldn't end a sentence with a preposition at.

Revolutionary France would be the perfect setting! Just think about the storyline: Robespierre and the other revolutionaries are Templars that foment a peasant revolution so that their man, Napoleon, can ascend to the French throne and go to war with the rest of Europe, to put the entire continent under the direct control of the organization. Imagine an assassin taking part in the storming of the Bastille, trying to rescue some key assassin prisoner before he is killed. You could have cutscenes of Marie Antoinette being decapitated!  
 
Not only that, but this is literally a time when actual assassins were running around! You could plan the assassination of Marat right along with Charlotte Corday! Hell, you could play as Charlotte Corday! 
 
(that's another good point by the way: wouldn't it be kinda fun if the protagonist was a woman this time around? I'm kinda done with the dudes)

It would be awesome if it was revolutionary France.  EVERYONE was out to kill and destroy anything that represented wealth at all.