Simple Question. 
Mine is the Army Carbine. Can be used up close, and from far away. Does a good bit of damage, also.

Musket

The better question is what's your favorite faction?
 
Mine's between Slingers and Gravers.

I really like the Scrap Musket, I don't know why.
 
Scrap Salvo is probably a big reason.

War Machete was awesome

I'm all in for the War Machete. Love them quick attacks.

Pike.  Incredible damage at a distance, can be equipped for knockback to keep them at that distance, and when playing with idols on, the negate armor ability to nullify Garmuth is amazing.

level 5 pike with all the left side upgrades... stupid op.

Calamity Cannon!

Dueling Pistols

The duelling pistols are awesome, lets you stay mobile while bringing the pain to your enemies

I really enjoyed the war machete.

Using that + something like the Army carbine is a great combo. Something for everything.

im liking the bow didst at first but begin able to do continues damage to some one and pierce through 5 or more enemy's is pretty good

Musket!   
Most of the game I played with musket and hammer. Not the fastest weapon combo, but lots of evading made it work really well.

I really really like the pike, I like the range you get with it.

Repeater with extra damage and ammo plus homing bolts, slaughters everything ever.

I enjoy prodding stuff with my pike.

Scrap Musket + Fire Bellows turns you into a moving apocalypse.

I gotta throw my support in for the bellows. So many foes run at you in this game then turning yourself into a walking inferno is always good. Pistols or musket can take care of the rest.

So far I'm really digging the War Machete.

Ended really loving the Fire Bellows. By the end I was taking too much heat while using melee weapons, so I ran a combination of the Fire Bellows + another, more powerful long range gun.

Army Carbine all the way! It's explosive shell at full upgrade level is ridiculously overpowered. I found that to be way more useful than armor piercing rounds.

My second weapon was the Fire Bellows. Anything armored or small swarms of enemies were toast with the bellows.

I'm most comfortable with the pike and duel pistols.

Ended really loving the Fire Bellows. By the end I was taking too much heat while using melee weapons, so I ran a combination of the Fire Bellows + another, more powerful long range gun.

The weapons I used the most were the Cael Hammer and Scrap Musket. The Musket is my favorite. Fun gun to use. :)

the bow just feels perfect, messed around with all of the weapons in my first play through, but the bow hits a real sweet spot with me, i tend to combine it with the scrap musket with knockback in case enemies get a bit too close its also good at taking out groups of small enemies, but the bow deals with 90% of the rest

going 200% crit damage on Machete, + dots, +werewhiskey, and scrap musket. When I'm doing good I'm doing poorly, and when I'm doing bad I'm killing everything.

I like how close to a bell curve this poll is.

Fire Bellows, definetly! It was the first weapon I got that ignored armor and together with that one tonic that restored your life as you dealt damage I was practically invinsible.

Everything must burn!!

Currently rolling with the Pike and Musket. The long reach of the Pike and the knockback from the Musket is great for spacing control.

Come on, guys. Breaker's Bow. The stacked poison upgrades works wonders against the Micia idol (regenerating health), and the damage over time counts towards leechade.

I was murdering fools with my bow left and right.