Cam Clarke is probably best known for his role as Liquid Snake in the Metal Gear series. He has also voiced many RPG characters in his career including; Kratos Aurion in Tales of Symphonia, Ryudo in Grandia II, Josh Calloway in the PS2 game Eve of Extinction, the playable male Blood Elf in World of Warcraft (added in the Burning Crusade expansion pack), and Prince Crescendo from Eternal Sonata. His career also includes a significant amount of voice acting in animated series, such as Shotaro Kaneda from Akira, Max Sterling and Lancer in Robotech, and Leonardo in Teenage Mutant Ninja Turtles.
Cam Clarke is also a singer who, in addition to providing the singing voice of Simba in The Lion King 2, released his own album in 1999 titled Inside Out. The album features covers of popular love songs, but modified to suit Cam's perspective as a gay man. For example, 'Son of a Preacher Man' appears on the album, but is sung from a male perspective.