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Aang is the lead character in the "Avatar: The Last Airbender/ Legend of Aang" games and cartoon. Aang is the reincarnation of the legendary Avatar that must master all four elements: air, water, earth and fire in order to bring balance to the world.
Crown prince of the fallen kingdom of Cornia, leader of the resistance to the Zenoiran Empire, and the main character of Unicorn Overlord.
Alex is the main character of Lunar: The Silver Star Story.
April is the reluctant heroine of the The Longest Journey, and reappears in Dreamfall as one of 3 playable main characters.
Aragorn, son of Arathorn is a character from the The Lord of the Rings franchise. He is a human ranger destined to become King of Men.
Once a warrior of Sigmar, now the current champion of Chaos Undivided, Archaon strives to bring about the End Times to the Warhammer Fantasy world. Despite this, he secretly loathes and plots against the Chaos Gods.
The Arisen is the fully customizable protagonist of Dragon's Dogma and is chosen by the Dragon when it removes his/her heart. The Default Arisen is a Male Strider named Glen.
King Arthur, the fabled ancient king of the British Isles, has made many appearances in video games. His story has been fodder for many tales, including Conquests of Camelot, the King Arthur games, and Dark Age of Camelot.
Prophesied in Necronomicon Ex-Mortis, the Book of the Dead, to be the medieval "Hero from the Sky", who (accidentally) tripped to the 13th century. Ashley is the ultimate deadite-slaying machine that managed to overthrow the Army of Darkness, mainly because he had the superior technological knowledge from the 20th century, his native times. He has a sidedown of being goofy at anything else (even being a housewares clerk), though, but he's still very competent at fighting deadites.
The player character in Dark Souls III.
The Avatar is the player character in the Ultima series. He (or she) is the embodiment of the eight Virtues and an example to the people of Britannia.
Details on the main character of the great graphic adventure game; Loom.
Buffy Summers is best known as a television character in the show Buffy the Vampire Slayer, who battled against vampires, demons, and other supernatural evils.
Caleb is a cynical, sarcastic man with a strong bent towards sadism, taking pleasure in killing almost anything that may impede his quest.
Colette is one of the protagonists of Tales of Symphonia. Most of the game centers around her and her quest to save the world.
Not necessarily "destined" to be anyone remarkable, Shepard eventually becomes the last pillar of hope for the entire Milky Way Galaxy in the face of inevitable doom from the Reapers.
Mother of the Dragons and (apparent) last of the Targaryens, Daenerys seeks to reclaim what she sees as her birthright and from there dramatically change Westeros or, as she puts it, "break the wheel".
Ancient prophecies told that the Chosen One will come to the galaxy far, far away to restore the balance to the Force. Nobody predicted that the Force was in perfect balance to begin with. But the prophecy had to be fulfilled nonetheless. So the Chosen One had to break the balance first, and then restore it.
The Demi-Fiend is the protagonist of Shin Megami Tensei: Nocturne. Half human, half demon, his powers are the deciding factor in the shape of the new creation to come.
The nameless protagonist of Shin Megami Tensei: Devil Survivor. His actions can alter the course of the game as he and his friends struggle to break free of the lock-down around the city.
The Last Dragonborn, who actually managed to bane Alduin the World-Eater from current times to the future. So the inevitable doom of the world will not come, at least not now, but in more or less distant future.
The one brought by the Fire Beast to either Destroy or Deliver the world.
Emperor of the Izumo Nation in Dragon Force for the Sega Saturn.
Another protagonist, also being called Estelle she wants to go outside of the barrier and see the world for herself.
Fei Fong Wong is the main character in the game Xenogears.
A hero chosen by the Greek gods to defeat the beast, Typhon, and save the ancient world.
The main heroine of Final Fantasy IX and heir to the throne of Alexandria. Well spoken and rather naive, she has the ability to summon Eidolons.
Harry Potter is the main protagonist in the Harry Potter universe. He became famous in the Wizarding world after his initial encounter with Voldemort that left him an orphan and a lightning-shaped scar on his forehead.
The younger brother of Amicia de Rune, and bearer of the mysterious disease Prima Macula
The most evil being in Albion who seeks nothing else, but power and destruction of the world. Very original.
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