Dan Vs. This Game is based on the TV show "Dan Vs.", which is about a scheming little man with a hair-trigger temper. Each episode revolves around him getting revenge on whatever angers him in that episode.
The levels of Dan Vs. This Game are loosely based on three episodes of the series: Dan Vs. The Dentist, Dan Vs. Canada, and Dan Vs. The Fancy Restaurant. Along the way, Dan can summon help from his only friend Chris, who gives him a boost over obstacles he can't jump over, or Chris' wife Elise, who attacks all on-screen enemies with a ninjato.