Deadly Creatures takes place in the Sedona Desert of Arizona. Players alternate between a tarantula and a scorpion each level. Billy Bob Thornton and Dennis Hopper lend their voices to the game, as human lowlifes searching the desert for a lost cache of riches.
Each insect has different methods of attack and abilities; the Scorpion is a great melee attacker, while the Tarantula fights more strategically. By pressing specific buttons and performing certain motions the insects vary their attacks.
Deadly Creatures is host to a fair amount of exploration aside from combat. Each creature can climb around the map and onto walls and ceilings, completing various objectives including collecting grubs and killing specific creatures.