Chang Tzu was is the scientific master of Oolong Island and employed as a weapon smith by Intergang. Chang Tzu established a collective of "mad" scientists dubbed the Science Squad. The Science Squad were chiefly responsible for bioengineering four immensely powerful beings, which came to be known as the Four Horsemen. One of the Science Squad members, Will Magnus, finally had enough of the evil being perpetuated by Chang Tzu's scientists and turned against them. With the aid of miniaturized versions of his Metal Men, Will Magnus killed Chang Tzu.
Chang Tzu showed up again in a different cyborg body, only to be defeated by Cassandra Cain, Power Girl and Wonder Woman. Though he has been killed on more than one occasion he never fails to reappear eventually. He has hinted that his "resurrections" are accomplished through cloning.