Seriously, these things are everywhere on the map and they are annoying as hell and so damn flighty just like the Cliff Racers form Morrowind. I remember in that game you try to go anywhere and you look behind you and there are like 4 Cliff Racers glitching out behind you trying to keep up, but you are constantly leaving their attack radius.  
 
The Cazador aren't AS prevalent as the Cliff Racers but they're definitely up there. They're a hell of a lot harder to kill than Cliff Racers though... 
 
I don't know why, but I'm getting a huge Morrowind feel to this game, more so than Fallout 3 and Oblivion. Anyone else feel me there? I'm thinking it's because of the unstable nature of the game :P

Cazadors killed my companions many times on hardcore mode :(   had to reload saves.

Cliff racers die easy and don't do much damage. Cazadors take some punishment to kill and hit like a cruise missile strapped to a ton of bricks. Racers were annoying. Cazadors are terror incarnate. 
 
Terror incarnate until I got the unique 40mm grenade MG Mercy, that is.

My answer for the Cazadors was the unique fire axe, Knock Knock.

They're those giant moth like creatures-of-death, right? I ignored the warning signs north of good springs, and an army of Mothra's TKO'd me.

I find Cazadors are easy to deal with in the same way that Deathclaws CAN be easy to deal with: cripple them. If you cripple their wings they flail about like a fly does when you rip off it's wings. Don't be shy now, we all do it.

Not a fan of the cazadors, but I think they offer up a hell of a nice challenge when I'm not on hardcore mode.  When I am, well... those sons of bitches are rough.  I've been using laser rifles and pistols to wipe them out fairly quickly.  For mid-to-late game hardcore stuff, my best perk sets have included anything that boosts or recharges AP fast, mostly due to these little bastards.

God yes, the Cazadors are the bane of my Fallout existence. I've gotten wrecked by those things so many times thus far, and am only now getting to the point where I can take them out reliably -- but usually not without still taking some damage. It's their venom that pisses me off the most, the outright damage they do to me isn't that big of a deal. 
   
Whenever they step to me I unload on them with the Heavy Incinerator or a Grenade launcher, that works pretty well for me now that I'm at a point now where I can take a few stings. When I get into the mid 20's in level I'm going to find the SPOILER WARNING: Click here to reveal hidden content. and get my fucking revenge for all the deaths they dealt to me in the game.

Right now I have ED-E and Boone with me so Boone manages to take them out a lot of the time. My Hunting Rifle is probably the best weapon I've found for them so far.

Their wings are very fragile and will make them much much slower if you cripple them.
So shoot them in the wings untill you get gear to just take them head on.
One you get some decent weapons they get easy to kill anyway.

" Seriously, these things are everywhere on the map   

" @xyzygy said:

" Seriously, these things are everywhere on the map   

 Really? I played through the game once on hardcore and never once encountered them. Only now, on my second playthrough, have I had the misfortune of engaging them (in the canyon spot north of Goodsprings). They are awful things though, especially on Hard difficulty. "

I hate running into Cazadors. ven't had to fight any Deathclaws yet but I think I would still hate the Cazadors more.
 
@xyzygy said:

" Right now I have ED-E and Boone with me so Boone manages to take them out a lot of the time."

Anti Material Rifle, Incendiary ammo. 
 
BOOM HEADSHOT

These things were a major pain to deal with at lower levels. Always there would end up being a whole group of them right in the way of my objective. What happened when I decided to go around and try to avoid them? Run into more. It was nice once I had the weapons to take them out from afar.

Just punch them. Punch everything except a deathclaw, win the game.

They knock you back. Its slightly annoying. But they'll probably be attacking Boone or something, so I guess come in from behind and punch it.

Cliff Racers were merely a nuisance. Cazadors rape your skull if you aren't paying attention.

It's hilarious to see that if you take twenty steps out of Goodsprings (the "newbie" area, if you will) in any nearly direction except for the one way out, you're gonna get ass-raped by Cazadors/Deathclaws/Radscorpions. I never knew about it when I left for the first time (I went the "correct" way to New Vegas, through Primm), but when I came back through the canyon I realized that Goodsprings is a fucking death-trap.
 
The NPCs do a good job of warning you, but man. That sleepy little town isn't going to be around much longer.

Use the flame-thrower on them cazadors.

At least Cliff Racers could provide some sense of humor...

Cliff racers were annoying. Cazadors on the other hand are lethally annoying. 
 
Are they trying to one up themselves in some sort of sick way?

I died two or three times to those things today. Got both me and Boone. 

What scares me the most about cazadors is that they're real.   
 
http://en.wikipedia.org/wiki/Tarantula_hawk       
  
edit: forgot my link

They wouldn't be so bad on their own, but they always come in groups.  If there are any Radscorpions in the area, you can try crossing their path.  Cazadors seem to hate radscorps and tend to forget about you and go after them.  Of course that distraction doesn't last terribly long.

what makes this especially dumb is that they are a big fly.
 
Sure deathclaws should be tough to kill, they are fucking huge muscle machines with massive claws.
 
A fly should not be able to take a hit from a plasma gun or shotgun and survive. Even giant ants are easy to kill by comparison and they have an exoskeleton. Hell, I could kill ants with one punch and knuckle dusters at level 12. Walked into a silver mine yesterday at level 30 with an RCW and idiotic cazadors wiped me out twice. They even survived a fucking mini-nuke. Stupid.

Hate these bloody bugs too, seems that most things in Fallout3 need AP rounds to do much to them. Another thing that seems to work with them is using something like the incinerator & running around while they burn or try to frenzy them with crits to the antenna & runing off. They seriously aren't worth the xp to me due to using lots of stims to repair limbs as well as armor.

" What scares me the most about cazadors is that they're real.   
 
http://en.wikipedia.org/wiki/Tarantula_hawk         edit: forgot my link "

Everything dies with Pushy. Except Deathclaws.