I can't reproduce it every time, but it happens frequently enough that I might as well mention it.
Playing a podcast on the regular-ass page (like "here's Beastcast Episode 217") and navigating the comments from Page 1 to Page 2 will stop the podcast, I'm assuming because a new HTTP request is made instead of something being done asynchronously (though I haven't done anything on my end to confirm that, so maybe it's just pausing the playback!).
When it happens, it only happens once; flipping the pages back and forth won't pause the playback again.
Chrome, Win7, Privacy Badger but no Adblock here on this website about video games.