I think the fact that the Switch doesn't support video out when undocked is actually a huge problem for any kind of "creation stream". It feels unlikely that they're going to do a Giant Bomb Makes Mario thing without using the touchscreen.
@gkhan: You're so right! I never really considered that this was an issue. With that said though, I have found myself creating levels with the controller, and after a brief learning period it's actually not THAT bad when you learn the shortcuts. Otherwise, maybe the duders could invest in a modded switch which allows the undocked output as seen here: https://youtu.be/FpGQznGKXdM?t=22