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Arcade is a supervillain/hitman in the Marvel Universe. He assassinates his victims by kidnapping them and setting them loose in a maze of deathtraps disguised as an amusement park called Murderworld.
The Greek god of war Ares in the Marvel Universe is often a villain, and was part of Norman Osborn's Dark Avengers.
Doctor Doom is a supervillain from the Marvel Universe who is bent on world domination. He is the ruler of Latveria and the primary antagonist of the Fantastic Four.
A powerful robotic servant of Doctor Doom, created in his image.
Dragon Man is a supervillain from the Marvel Comics universe. He is a dragon-like human who was created by alchemy.
Eddie Brock is a character in the Marvel Universe best known as Venom. He became Venom when he joined with an alien symbiote life form and was one of the most fearsome enemies of Spider-Man. He has also use the Anti-Venom and Toxin symbiotes at different points in his life.
The Sandman, also known as Flint Marko or William Baker, is a Marvel Comics character and a regular enemy of Spider-Man. He has occasionally been a superhero, and even briefly was a reserve member of the Avengers.
Galactus is the devourer of worlds. He is nearly omnipotent.
Grey Gargoyle is from the Marvel Comics universe. He was a French chemist who developed his powers by spilling an unknown chemical mixture on himself.
Impossible Man is an alien being who often causes trouble for The Hulk and Fantastic Four.
The editor-in-chief of the Daily Bugle in Spider-Man games. Has an agenda against the wall-crawler. He is portrayed by J.K. Simmons in the Sam Raimi Spider-Man Trilogy and the Marvel Cinematic Universe.
Mephisto is from the Marvel Comics universe. He rules the land of the dead.
Onslaught is a villain in the Marvel Universe, created when Professor Charles Xavier erased the mind of Magneto, and his psychic essence combined with the evil in Xavier's mind... or something.
Paibok is from the Marvel Comics universe. He is a super powered skrull.
Ruby Thursday is a supervillainess whose head was replaced with a techno-organic ball.
Anath-Na Mut was a sorcerer who was expelled from Ramses II's court after being outperformed by Moses. Now immortal, he tours the universe seeking death.
Super-Skrull is from the Marvel Comics universe. He is from Tarnax IV which has since been destroyed by Galactus and first appeared in Fantastic Four #18(1963).
A fictional villain in the Marvel universe with the ability to copy the physical movements of anyone he observes. He has used these skills to gain fame and fortune, and also a government mandated job.
Thanos is a purple alien from Marvel Comics. He was a final boss in Marvel Super Heroes and Marvel Super Heroes: War of the Gems, and was a playable character in Marvel vs. Capcom 2: New Age of Heroes.
The Wink is a former stage magician. She was given teleportation and phasing powers by Niles Van Roekel.
In the Marvel Universe, Titania is a superhuman powerhouse and arch-enemy of She-Hulk.
Ultron is from the Marvel Comics universe. Ultron began his story disguised as the Crimson Cowl and is chiefly an enemy of the Avengers.
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