I've been doing a bit of thinking after finishing the game, and I'm trying to decide if I want a third game or not. Part of me loves the memories I know I'll have of the series, and how they're my favorite exclusives on the PS3, but the other is selfish, and wants to play more. Personally, I've done a bit of thinking and I have an idea about how it could happen:
Scenario 1 (Good Ending)
Watch this video and look closely at this video. Lightening strikes Cole in a '?', which I interpret as the bolt bringing him back to life. If that is the case, then in inFamous 3, another power-hungry man begins development on his own machine that could make him a Conduit, taking advantage of Cole and all of the other ones dying. The machine works, and Cole needs to stop him.
Scenario 2 (Evil Ending)
The power-hungry man sees Cole killing those without the Conduit gene and decides to act, attempting (and succeeding) to make himself a Conduit to fight Cole and his army.
Scenario 3 (No inFamous 2 Save)
Just the power-hungry man becoming a Conduit and you have to stop him somehow.
The biggest problem is Zeke, since, you know, you kill him in the Evil ending. But that could be solved by having the bad guy kill Zeke in the early minutes of the game for the Good and "Virgin" (lack of a better term) players. I dunno, could be weird since I'm happy with the endings, but dammit I love me some inFamous. What say you? Do you want an inFamous 3?