What are the best ones you can think of? My personal fav is "It WAS rather poopsome"

this will be redirected by MB, I can almost guarantee it. 
 
EDIT:  "Get to a Serotonin Re-Uptake Inhibitor... IMMEDIATELY!!!"  "Anime is for Jerks."

"OHHH SHIIIIT!"   

Dragonball is dumb.                                                                                                                                 ....but not as much as the people who like it.
 
 
First thing I thought of.

"This is my favorite part of the set" -Jeff from the most recent bombcast with the synthesizer.

--Keepin' it pretty webi-nar-nar bro! 
 
--You can't beat 100%, the only real power is power, and double-decker tacos are pretty awesome. 
 
--It was hella spies! 
 
--Oh, DOWN!.... Phoenix down! 
 
 
Those are my faves.

Ryan: Jeff likes sandwiches and new releases
Jeff: Often at times eating a sandwich will lead to a new release

The whole hotspot bit about "Gaming for me is a religion, and Haze is the shit". Everything he says there is gold. 
  

  "Build a city full of synthetic people to trick a sailor '''.

" The whole hotspot bit about "Gaming for me is a religion, and Haze is the shit". Everything he says there is gold. 
  

"

Jeff is an ordinary and every-day-guy like you and me.. nothing he says is THAT quotable or remarkable... each and every one of us says funny random shit a few times a day, just like the GB crew does

  "Yeah, no, I'm sure it looked awesome."

Sorry for bumping this, but the quote "____ is a religion, and _______ is the shit" was stuck in my head for some reason for the past few days and I knew Jeff had said it at one time, so googled it and came to this thread. Thank you for finding this gem, my favorite Jeff quote by far.

"I don't want to act unprofessionally and say things that I'll regret later... but this is the 9/11 of video games"

- Jeff Gerstmann (speaking about Beverly Hills Cop for the the PS2 during Unprofessional Friday)

Short, but sweet.

"drop'em"

Where's that "easier than free" quote?

You can't defend against nonsense! -Jeff

Said upon losing to Patrick who button mashed his way to victory in a SF4 TNT.

"Hook my mouth up to that dog's ass!"

"No one is more authentic than Kid Rock!" - Jeff

''Shut your whore mouth'' at York during the VJ endurance run.

SOMETHING SOMETHING HOT GARBAGE.

I can't find the bombcast it was in so I might be paraphrasing a bit. During a discussion about (I think) milk and Pepsi, Ryan mentioned putting peanuts into Pepsi and watching them dance.

Jeff: "Ooh, dancin' peanuts! Now I'm on board!"

'Only the dead see the end of war'

- Gersto

Distinct lack of "Gay sexual content," "More safari, less track," and who could forget "this game makes me want to kill myself."

From a Bombcast a few weeks ago when Brad said that even though it didn't affect everyone he was happy about Microsoft lifting the limit on your friends list in the next-gen Xbox:

Jeff: "We get it, you're popular."

I almost drove off the road laughing.

''Tell mister mustache to eat a dick straight up''

THE SHMOO IS REAL!!!

"Hi Ryan."

"You can see their panties." - Jeff Gerstmann

“Ha! Dude, no seriously, I’m hungry!”

"Before I die, I'm gonna fuck me a fish." - Endless Ocean Blue World QL

"Get a girl pregnant."

"This is our secret...Secret medallion hurmhurmhurm."

"No, Centipede was huge. Don't be crazy. Don't mess up. Don't... talkin' mess now about Centipede."

"How are you liking me stabbing you in the bitch, bitch!"

"I am going to stab you now in the bitch with my boot knife"

"I don't like this one bit."

@equitasinvictus: I like how that is pretty much his only accent

@pie: That's true! I think he totally did it again during the Mars: War Logs QL too even though no one really sounded like that. (Although one could argue there wasn't even a consistent accent for the game's dialogue anyway!)

I don't know if it's my favorite but on the 5/7 bombcast Brad is talking about experiencing pain while playing DOTA and just powering through it and slightly off mic you hear Jeff say "..........you're gonna die...." and I lost my shit immediately and replayed it 3-4 times and it always kills me.