Manny is introduced to Niko Bellic in the first quarter of the game by his close friend Mallorie. After a fairly bad start, including the smashing of Jay’s camera, Niko is given a mission by
Manny to follow some dealers, and then take them all out when he reaches their base of operations. His next mission sees Niko taking out more gang members and drug pushers, and Niko meets Francis McReary, and it appears that many is working alongside Francis to clean the neighborhood up. After this mission, Manny gives Niko a mission to take out some of his old friends making fun of him and implying that he is homosexual due to his videos. This involves Niko chasing down a train and taking out more gang members. His annoying nature and in your face attitude turns out badly, when he tries to film Elizebeta taking drugs, during a period of the game where Elizebeta is very paranoid due to police pressure. He is promptly shot in the head, along with Jay, and Niko is tasked with delivering their bodies to an organ donor in Dukes, and after a comment from the surgeon Niko states that "He'd been trying to help the streets his whole life...maybe he'll be actually doing it now.", regarding the fact that the organs could actually help people.
- Escuela of the Streets (Boss)
- Street Sweeper (Boss)
- The Puerto Rican Connection (Boss)
- Have a Heart (Killed)
- Manny Escuela is voiced by Berto Colon.
- Manny claims that he invented rap music.