I pretty much took almost every class to 20 now.
For pure dmg spam and best overall support is Asari Adept, warp+throw with lowered cooldowns can be used to spam biotic combinations at an insane rate, this is the fastest way to take down all the elite enemies like Banshees, Brutes, Primes, etc ... from a distance. Combine with the Bubble stasis and you have the best crowd controll. The only huge downside is the extreme fragility of the class. A true glass cannon. But the ranged power you wield is tremendous and unparallel.
Vanguard is fun to fool around on bronze, but unfortunately there are mechanical problems with the MP that sometimes make you not able to charge even when off cooldown, making you die, since you're still fragile. Reliance on cooldown means light weapons only. It's also too risky charging elite enemies. Its a fun class nonetheless and can outscore others easily in good hands. But not a fan personally. Nonetheless it would be amiss not to mention as the most newbie friendly class that can do great.
Krogan Berzerker Sentinel, my favourite class, you have the most damage protection then anyone (60-70% reduction when raging), more shields, more health, you are basically a walking tank. Like I mentioned before while you are raging (mele 2 enemies) you can one shot any enemy in melee even shielded ones, bar elites and do tremendous damage to those. This outputs the most damage of any class on silver. (on gold asari adept might overtake him due to biotic explosions scaling with difficulty) You can sport the best heaviest weapons too, not giving a damn for cooldowns. With a Claymore nothing takes down elites faster then you. Not only are you a tank, you are also the cannon without the glass part. The reason to take Krogan Adept over Soldier is that the shield ability gives extra melee damage.
Quarian Infiltrator is the bees knees against geth and a very capable class to play with sticky grenades, cloak, sabotage. If it was not for some issues this would be an almost OP class. Issues: cloak frequently does not work and enemies will continue to see you, this is especially true if the rest of your team is down cloak is basically useless. I sometimes get into games with lag, making sniping almost impossible, due to shitty ME netcode. When pressed into a corner (like wave 11) the supreme power of this class is instantly degraded. This is also the easiest class to use 4 of on gold to farm credits against geth enemies (not personally tested unlike the rest of this post).
Quarian Engineer, great support for your team, you can lay down the turret and spam Cryoblast and Incenerate between shots in alteration, this is a great way of debuffing the enemy, and resulting tech explosions spread to others. Highly recomend using cryo rounds however on silver and above to help set up and off tech explosions. It a very good debuff class, making it much easier for the rest of your team to take down tough enemies or manage groups, you can literaly make elites go down twice as fast. Great against all enemy types, well rounded class choice overall. And no real big drawback, which is why it's in this list.
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