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Murphy is encountered in the Sales Office during the middle of the story. He is always found to be gravely injured, though depending on choices prior, Jill Valentine will either find him shot dead by Nicholai Ginovaef as Murphy pleads for his life; or with Murphy contrastingly pleading Carlos Oliveira to kill him. Carlos complies, but will run out of the Office soon after, clearly distraught after having to kill his friend.

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