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Natalie was a natural born athlete, but from an early age she was diagnosed with a brain disorder, it didn't affect her learning or speaking skills, but it did make here have hallucinations, usually of demonic beasts, but she has lived her life through a haze of medical drugs, keeping her condition stable. 
Since the infection broke out she has been fighting the real demons. 
'Finally a demon I can actually kill' is Natalie's motto. 
Natalie is most likely Left 4 Dead's Zoey, but opposite, Natalie is older than Zoey and Natalie has a mecial condition whereas Zoey is still attending college/university and appears to be perfectly healthy.

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