So, I just watched Zero Punctuation's review on Nier Automata, and has seen that the humans have a high chance of already being dead on the moon and that 9S would die... in tthe third playthrough?

That's what I got from it. I stopped viewing halfway through. Is this even true or... is it that big of a spoiler? Thank you!

If you played the first Nier you would already know humanity is extinct. You just lose out on the mystery of whether something weird happened to bring them back. (Nope as it turns out.)

It's a big plot point, but more for the characters than the player. Don't worry, there are way way crazier revelations in store.

Humanity's fate is fairly easy to guess early on in Automata so no, that's not that big a spoiler. If you were planning on playing it and think that you've ruined the story for yourself by learning those things, you most certainly did not.

As Yahtzee puts it in his video, the game is not about that, so regardless if it's true or not, it should not hinder your enjoyment of the game. Automata is much less about the actual events and more about the philosophical meanings behind them.

Neither of those things is a spoiler by the time you get to them. Humanity's fate and 9S' fate are basically low-balled to you way before they actually show you.

Oh okay! Thanks for the answers! I wanted to buy the game and was afraid that this would spoil the experience! I'll buy it and play it then! Thanks again!