Your ME3 playthrough will be significantly diminished without Tali. Personally, I lost a squadmate in the suicide mission and restarted it. I didn't want to miss out on any content in ME3. Which, in retrospect, would've happened if I didn't redo the mission.
Fortunately, I like Castlevania enough to play through it multiple times. I'm a little bummed out about no XP gaining though. Seems like there will be a much smaller sense of progress when there's not a number assigned to it.
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