The update seems to cause instant VATS crashes on my end. Regardless of the weapon I have equipped or the target, I'm now pretty scared to hit RB. So I cleared my system cache to restore the original pre-update build and now I'm okay again. Guess I'll just have to play offline until I get a little more feedback. It's still pretty early for a consensus, but at least one other person on the Bethesda forums is having the same problem. The only commonality so far is that we're both loading up saves in Nipton; another user loading up on The Strip is doing fine, so... who knows?