I really wasn't interested in Fallout 4 after seeing them rework Special and the PERKs system and was holding out for Obsidian or any of the interplay veterans to be involved in a new Fallout game. My fear is we won't see a normal Fallout game for some time if this is a success as their focus on the IP will be on 76 and nothing else.
I heard some pretty interesting things regarding timing and missions; that is if you don't do a mission in time you completely miss out on certain key events, and maybe ignore the main story completely. In my mind this is 'realistic Skyrim' but who knows for sure until it ships.
I'd be interested if they dialed back some of the Civ 5 changes, or atleast had a good overhaul on how the game works. I really wanted to like Civ V but the pace of the game was really slowed down to a crawl with how much the game penalized making new cities with it's Happiness, Culture, and Science mechanics, and then to take cities over just to have them sit there as 'puppet states' was really annoying too.
The diplomatic AI could also use improvements and I'd take smart AI over 'we're out to get the player' AI any day of the week.
If anything they now have way more freedom to do whatever they want story wise/gameplay wise because they have no lore to adhere to; they had debates of whether or not they should introduce a crossbow in Witcher 3. Cyberpunk is dark in general, and probably has more of a presence in video games than dark fantasy does, so it will be interesting to see what they could explore and do that would be fresh by comparison.