The nature of para-social relationships on the Internet is that when there's a radical staff change like this it feels like someone just jumped out from behind a dumpster and shot your little sister, for no discernable reason (not that there's any good reason to shoot my little sister, mind you). So, emotionally speaking, it doesn't feel great right now.
That being said, seeing the GB formula change and develop in new directions might not be such a bad thing. I've been religiously consuming Giant Bomb content since the site started (and followed Jeff & Co. long before that), but mostly for the staff members as specific personalities and not for what they're actually doing (i.e. playing games on the Internet, which everyone does these days). In that context, it will definitely be interesting to see if GB can carve out a new niche for itself in the weird online multiverse of 2021.