Bison makes an excellent burger, but you have to prepare it a bit differently. Bison isn't as fatty as beef, so it dries out faster.
Start with good quality, fresh bison if you can get it. Put it in a bowl, and add some liquid to it to keep it moist. Worcestershire sauce is always good, but you could try a dash of red wine, scotch whiskey, Coca Cola(!) or anything else you might have lying around. Don't add too much, you just want a few tablespoons or so.
Now, if you like onions, I suggest some sweet vidalia onions, chopped fine and added directly to the meat. Make sure to add some kosher salt and pepper, and perhaps some garlic powder if you like.
Mix everything together, but be careful not to knead the meat to much. Use your hands to blend the meat loosely, and then form it into patties. Remember, you don't want to work it too much, this will make the patties too dense. Generally speaking, you can get 3 or 4 patties from a pound of meat, just like with ground beef.
Pan fry or grill (the best way) the patties over high heat. They won't take as long to cook, so for 1/4 pound patties you're looking at 3-4 minutes per side.
My favorite topping for bison burgers is a big slab of quality blue cheese- the pungent, creaminess of the cheese is a perfect compliment to the slight gaminess of the bison. Enjoy!

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