One thing I have found with running a quad core system is if you disable 2 cores for the app it can run a hell of a lot more stable.
To disable cores, start the game. Then bring up the task manager (alt+ctrl+del) and go to processes. Find the borderlands.exe process and right click on it and select select affinity. Then uncheck 2 cores. Run the game.
It may not help but it helps me run several PC games (DOWII, L4D, Fallout 3)

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