A lot of things point at the squad shaping up to look differently depending on previous choices, new ones in ME3 and so on. Considering both Tali and Garrus (and the rest of the ME2 crew) can be dead, the setup has to be a bit more dynamic in ME3.
There will probably be quite a lot of conflicts even after the Reapers are defeated (?) and the galaxy tries to rebuild what was destroyed, so a save would definitely add a lot of depth to a new series featuring someone else than Shepard.
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