This is a bad category. I'm with Jeff (22 minutes in) where my impression was the category was about the best realized world (narrative/characters/locations/lore). Vinny/Brad/Abby definitely seem to be talking about the best sandbox to play in.
I think if this series was made entirely in 2015, these guys would have had an argument for KSP occupying all the slots for "Best/Most Memorable Moment"
This series is soooooooooo good. Might be worth looking up a view quick tips for extra success, though. It will still be challenging, even with some pointers.
Here's a couple quick ones:
1) Once you break that first layer of atmosphere on launch, tilt to 45 degrees (generally eastward) to build both height and orbital velocity. Not the most efficient, but fairly fool proof.
2) If you've made an orbit with a wonky angle, make your corrections where the plane of your orbit and the Mun's orbit intersect. This is where you'll have the most fuel efficient maneuvers for realigning yourself (This is where you use the purple maneuver nodes).
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